发明名称 |
BEAD BOUND COMBINATORIAL OLIGONUCLEOSIDE PHOSPHOROTHIOATE AND PHOSPHORODITHIOATE APTAMER LIBRARIES |
摘要 |
The present invention includes composition and methods for making and using a combinatorial library having two or more beads, wherein attached to each bead is a unique nucleic acid aptamer that have disposed thereon a unique sequence. The library aptamers may be attached covalently to the one or more beads, which may be polystyrene beads. The aptamers may include phosphorothioate, phosphorodithioate and/or methylphosphonate linkages and may be single or double stranded DNA, RNA, or even PNAs. |
申请公布号 |
WO2005003291(A2) |
申请公布日期 |
2005.01.13 |
申请号 |
WO2003US32218 |
申请日期 |
2003.10.14 |
申请人 |
BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
GORENSTEIN, DAVID, G.;YANG, XIAN, BIN;LUXON, BRUCE, A.;HERZOG, NORBERT |
分类号 |
C07H19/00;C07H21/00;C12N;C12N1/00;C12Q1/68;C40B40/06;C40B60/14;G01N33/53;G01N33/543;G01N33/68 |
主分类号 |
C07H19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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