| 摘要 |
1338493 Chemical sterilization BIOLOGICAL CONCEPTS Inc 29 Oct 1971 [12 Nov 1970 50358/71 Heading A5B Compositions which achieve sterilization of mamalian reproductive organs when introduced into a gamete-carrying duct comprise copper ions or a chelating agent for zinc ions and an acridine derivative of the formula: wherein R is H, OH or etherified or esterified hydroxy, R 1 is halogen or mono- or di-alkylamino in which the alkyl groups have up to 10 C atoms and R 2 and R 3 (which may differ) are each H, alkyl, amino or mono- or dialkylamino in which the alkyl groups may be additional amino, mono- or di-alkylamino groups. The method of inhibiting fertility in mammals (other than for treating disease in humans) by administering the compositions is also claimed. A large number of zinc-chelating compounds are mentioned, e.g. amino and amino-acids. |
