| 摘要 |
The present invention provides benzamide inhibitors of the P2X7 receptor of the formula: wherein R<1>-R<3 >are as defined herein. The compounds of the invention are useful in the treatment of IL-1 mediated disorders, including, without limitation, inflammatory diseases such as osteoarthritis and rheumatoid arthritis; allergies, asthma, COPD, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.
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