| 摘要 |
Protide compounds of formula (I) wherein X represents H, F, N3, NH2, -CN, or -OMe; X<1 >represents O or NR<7>; X<2 >represents O, NH, NR<6 >or S, or when X<3 >is O then X<2 >is absent; X<3 >is absent, or when X<1 >is O then X<3 >represents O; R<1 >represents hydrogen; optionally substituted C1-6alkyl; optionally substituted aryl; or optionally substituted heteroaryl; R<2 >represents hydroxy, OCOR<6>, or OCO2R<6>; R<3 >represents H, optionally substituted C1-6alkyl, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl; R<4 >and R<5 >are independently selected from hydrogen, optionally substituted C1-6alkyl, optionally substituted aryl, or optionally substituted aralkyl; R<6 >represents optionally substituted C1-6alkyl or optionally substituted aryl; R<7 >represents H, optionally substituted C1-6alkyl, or optionally substituted aryl, wherein when R<4 >and R<7 >are each alkyl they may be linked to form a 5- or 6-membered ring; B represents (a), (b), (c), or (d) wherein Z represents O or S; R<8 >represents H, halo, C2-4alkynyl, trifluoromethyl, C1-3alkoxy, hydroxy, methylthio, amino, nitro, or C1-3alkyl wherein the C1-3alkyl may be optionally substituted by hydroxy, halo, amino, or OR<10 >wherein R<10 >represents C1-6alkyl optionally substituted by aryl which may itself be optionally substituted; and R<9 >represents H, halo, hydroxy, OR<6>, SR<6 >or NR<3>R<3>; are useful in the treatment of viral infection, particularly HCV infection.
|
