| 摘要 |
PROBLEM TO BE SOLVED: To provide a new compound having leukotriene (especially, leukotriene B4) inhibitory action and useful for preventing/treating disease, such as allergy, asthma, and inflammation. SOLUTION: A pharmaceutical composition contains the new benzofran compound having general formula (I) [Z is expressed as Z<SP>a</SP>, Z<SP>b</SP>or Z<SP>d</SP>; X<SP>1</SP>to X<SP>8</SP>are each a bond, O or the like; Y<SP>1</SP>and Y<SP>2</SP>are each H, a halogen or the like; R<SP>1</SP>and R<SP>2</SP>are each a substituted or unsubstituted 1-6C alkyl, a substituted or unsubstituted 6-14C aryl or the like; R<SP>3</SP>is a 1-6C alkyl or the like; R<SP>4</SP>is -CO-NR<SP>5</SP>R<SP>6</SP>(R<SP>5</SP>and R<SP>6</SP>are each a 1-6C alkyl which may be substituted, a 6-14C aryl which may be substituted or the like) or the like; R<SP>9</SP>is cyano or the like; R<SP>10</SP>and R<SP>11</SP>are each a 1-6C alkyl, hydroxy or the like; and R<SP>15</SP>is a 1-6C alkyl or the like], its pharmaceutically acceptable salt, etc. COPYRIGHT: (C)2005,JPO&NCIPI
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