| 摘要 |
The invention relates to a method for producing 4-haloalkylnicotinamides having the formula (I): wherein R<SUP>1 </SUP>is (C<SUB>1</SUB>-C<SUB>4</SUB>)haloalky, comprising subjecting one or more 3-((C<SUB>1</SUB>-C<SUB>4</SUB>)haloalkyl-3-oxo-1-alkenylamino)nitriles of the formula (II), (III) or (IV): <?in-line-formulae description="In-line Formulae" end="lead"?>R<SUP>1</SUP>-C(O)-CH-CH-NH-CH-CH-CN (II) <?in-line-formulae description="In-line Formulae" end="tail"?> <?in-line-formulae description="In-line Formulae" end="lead"?>R<SUP>1</SUP>-C(O)-CH-CH-NH-CH(ZR<SUP>2</SUP>)-CH<SUB>2</SUB>-CN (III) <?in-line-formulae description="In-line Formulae" end="tail"?> <?in-line-formulae description="In-line Formulae" end="lead"?>R<SUP>1</SUP>-C(O)-CH-CH-NH-CH(Hal)-CH<SUB>2</SUB>-CN (IV) <?in-line-formulae description="In-line Formulae" end="tail"?> where R<SUP>1 </SUP>is as defined above, R<SUP>2 </SUP>is the same or different and is (C<SUB>1</SUB>-C<SUB>6</SUB>)-alkyl and Z is the same or different and is O, S or NR<SUP>1</SUP>, to a ring-closing reaction and simultaneous hydrolysis in the presence of a strong acid.
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