OPTICAL ISOMER SEPARATION PACKING FOR SIMULATED MOVING BED CHROMATOGRAPHY

摘要

The present invention provides a filler having a high productivity suitable for preparative separation by simulated moving bed chromatography. That is, there is provided a filler for enantiomeric isomer separation by simulated moving bed chromatography, which has a porous carrier carrying a polysaccharide derivative thereon and has a TS coefficient in a range of 0.55 to 1.20, the TS coefficient being defined by the below-shown formula (I), abd obtained by using an enantiomeric isomer separation column for simulated moving bed chromatography in which the filler is filled in a column tube by a slurry filling method: <DF NUM="(I)">TS coefficient = ÄVc - Ät(TS) - t(blank)Ü x FRÜ / Ät(TS) - t (blank)Ü x FR </DF> (wherein abbreviations mean the following: Vc (cm<3>): a column volume; FR (ml/min.): a flow velocity; t(TS) (min.): an elution time for tetrakis(trimethylsilyl)silane (= TS); and t(blank) (min.): an elution time for TS in the state where the column is not connected).