Novel compounds having activity against trypsin are disclosed. Specifically, novel peptide aldehyde analogues that have substantial potency and specificity as inhibitors of mammalian pancreatic trypsin are presented. The compounds are useful in the prevention and treatment of the tissue damage or destruction associated with pancreatitis.
申请公布号
CA2128711(C)
申请公布日期
2005.01.11
申请号
CA19932128711
申请日期
1993.01.29
申请人
CORVAS INTERNATIONAL, INC.
发明人
BRUNCK, TERENCE K.;PEPE, MICHAEL G.;PEARSON, DANIEL A.;WEBB, THOMAS R.
