发明名称 |
Transcription factor E2F DNA-binding domain inhibitor peptides and their use |
摘要 |
The present invention provides peptides which bind to the DNA binding domain of transcription factor E2F, and inhibit cell cycle progression. Peptides include FWLRFT (SEQ ID NO:1); WVRWHF (SEQ ID NO:2); WHFIFW (SEQ ID NO:3); IWLSGLSRGVWVSFP (SEQ ID NO:4); and GSRILTFRSGSWYAS (SEQ ID NO:5) and derivatives based upon these sequences. Compositions and the use of the peptides in inhibiting cell cycle progression, such as in uncontrolled cell proliferation, are also provided.
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申请公布号 |
US6841385(B2) |
申请公布日期 |
2005.01.11 |
申请号 |
US20010912414 |
申请日期 |
2001.07.26 |
申请人 |
TOPOTARGET UK LIMITED |
发明人 |
MUELLER ROLF;KONTERMANN ROLAND E.;MONTIGIANI SILVIA |
分类号 |
A61K38/00;C07K7/06;C07K7/08;C07K14/47;C12N5/02;(IPC1-7):C12N5/02;C07K7/00;C07K14/00;C07K14/435;C07K19/00;A61K39/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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