发明名称 |
Rekombinant anti-HIV antistof og fremstilling deraf |
摘要 |
The invention relates to a gene fragment which codes for the variable regions of an antibody having an activity of neutralizing human immunodeficiency virus (HIV), a novel recombinant anti-HIV antibody expressed by using the above gene, and a process for preparing the same. A mouse-human chimeric antibody and a modified mouse-human antibody, having an activity of neutralizing HIV, are obtained by determining a specific nucleic acid sequence of a gene fragment which codes for the variable regions of the H and L chains of an antibody having an activity of neutralizing HIV and artificially fusing a DNA synthesized on the basis of the determined sequence with a gene which codes for human immunoglobulin. The novel anti-HIV antibody is useful for treating and preventing AIDS. |
申请公布号 |
DK0678523(T3) |
申请公布日期 |
2005.01.10 |
申请号 |
DK19930901547T |
申请日期 |
1993.01.14 |
申请人 |
JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE |
发明人 |
OSATOMI, KIYOSHI PANA HAITSU 102;MAEDA, HIROAKI;KIMACHI, KAZUHIKO;EDA, YASUYUKI;SHIOSAKI, KOUICHI;TOKIYOSHI, SACHIO |
分类号 |
A61K38/00;A61K39/395;C07K16/10;C12N15/13;C12P21/08;(IPC1-7):C07K16/10;C07K15/28 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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