СПОСОБ ПОЛУЧЕНИЯ БЕТУЛИНОВОЙ КИСЛОТЫ

摘要

FIELD: chemical technology, natural materials, medicine, pharmacy. ^ SUBSTANCE: invention relates to the improved method for preparing betulin from betulinic acid that can be used in preparing anti-tumor and anti-HIV medicinal preparations. Method for preparing betulinic acid involves oxidation of betulin with chrome (VI) oxide in acetic acid to betulonic acid and reduction with sodium boron hydride to betulinic acid. Betulonic acid sodium salt is reduced to betulinic acid and reduction reaction is carried out at room temperature at the concentration of sodium boron hydride 1.0-6.0 wt.-%. Invention provides simplifying method for preparing betulinic acid, reducing its cost and enhancing ecological safety of the process of it producing. ^ EFFECT: improved preparing method. ^ 1 cl, 4 ex