POLY-GAMMA-GLUTAMIC CONJUGATES FOR ELICITING IMMUNE RESPONSES DIRECTED AGAINST BACILLI

摘要

Immunogenic compositions and methods for eliciting an immune response against B. anthracis and other bacilli are provided that include immunogenic conjugates of a poly-gamma-glutamic acid (gammaPGA) polypeptides of B. anthracis, or of another Bacillus that expresses a gammaPGA polypeptide. The gammaPGA conjugates elicit an effective immune response against B. anthracis, or against another Bacillus, in mammalian hosts to which the conjugates are administered. The preferred conjugate consists of gamma-D-PGA and Bacillus protective antigen.