METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS
摘要
This application relates to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and an antibody to alpha 4 integrin or an immunologically active antigen binding fragment in therapeutically effective amounts. The application also relates generally to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and small molecu le alpha-4 integrin antagonist that inhibits the alpha-4 integrin ( 4 integrin) interaction with VCAM-1. The invention further relates to methods of prepari ng the compounds and methods of using the compounds and compositions.
申请公布号
CA2529873(A1)
申请公布日期
2005.01.06
申请号
CA20042529873
申请日期
2004.06.25
申请人
ELAN PHARMACEUTICALS, INC.
发明人
KONRADI, ANDREI W.;PLEISS, MICHAEL A.;FREEDMAN, STEPHEN B.;LIEBERBURG, IVAN;SHOPP, GEORGE;MESSERSMITH, ELIZABETH;YEDNOCK, THEODORE A.