发明名称 |
TREATMENT OF PROTEIN AGGREGATION DISORDERS |
摘要 |
The present invention is based, at least in part on the discovery of therapeutic agents capable of preventing, inhibiting or modulating abnormal processing, misfolding or aggregation of protein. The therapeutic agents of the invention may prevent, inhibit or modulate the formation of inclusions. The therapeutic agents of the invention may also be capable of facilitating clearance and/or blocking the cellular toxicity of inclusions to treat or ameliorate disorders characterized by protein aggregation. Compounds which bind to structural motifs commonly found in protein aggregates, such as .szlig.-sheets, would represent strong candidates for such compounds and are therefore desirable.
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申请公布号 |
CA2528627(A1) |
申请公布日期 |
2005.01.06 |
申请号 |
CA20042528627 |
申请日期 |
2004.06.21 |
申请人 |
NEUROCHEM (INTERNATIONAL) LIMITED |
发明人 |
MCLAUGHLIN, RICHARD;TREMBLAY, PATRICK |
分类号 |
A61K31/185;A61K31/445;A61K31/495;A61P25/00;A61P25/16;A61P25/28 |
主分类号 |
A61K31/185 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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