Therapeutic and diagnostic domain 1 beta2GP1 polypeptides and methods of using same

摘要

The present invention provides domain 1 beta2GPI polypeptides, polynucleotides encoding these polypeptides, mimetics of these polypeptides, and methods using domain 1 beta2GPI polypeptides and mimetics. Domain 1 of beta2GPI has been shown to bind to anti-cardiolipin (beta2GPI-dependent antiphospholipid) antibodies, which are associated with several pathologies, such as thrombosis and fetal loss. The domain 1 beta2GPI polypeptides may be used to detect beta2GPI-dependent antiphospholipid antibodies in a sample. The invention further provides methods of inducing tolerance using these domain 1 beta2GPI polypeptides.