| 摘要 |
The present invention relates to interferon-immunoglobulin Fc fusion proteins (referred to as "IFN-Fc hybrids") and their use in treating tumors and viral infections. The IFN-Fc hybrids may include linkers between the interferon molecule and the immunoglobulin Fc fragment. These linkers are preferably composed of a T cell inert sequence, or any non-immunogenic sequence, including Gly-Ser repeat units ranging from 2 to 40 amino acids. The preferred Fc fragment is a human immunoglobulin Fc fragment, preferably the gamma4 chain.
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