发明名称 |
Polyvalent protein complex |
摘要 |
The invention provides for a polyvalent protein complex (PPC) comprising two polypeptide chains generally arranged laterally to one another. Each polypeptide chain typically comprises 3 or 4 "v-regions", which comprise amino acid sequences capable of forming an antigen binding site when matched with a corresponding v-region on the opposite polypeptide chain. Up to about 6 "v-regions" can be used on each polypeptide chain. The v-regions of each polypeptide chain are connected linearly to one another and may be connected by interspersed linking regions. When arranged in the form of the PPC, the v-regions on each polypeptide chain form individual antigen binding sites.
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申请公布号 |
US2005003403(A1) |
申请公布日期 |
2005.01.06 |
申请号 |
US20040829388 |
申请日期 |
2004.04.22 |
申请人 |
ROSSI EDMUND A.;CHANG CHIEN HSING;MCBRIDE WILLIAM JOHN |
发明人 |
ROSSI EDMUND A.;CHANG CHIEN HSING;MCBRIDE WILLIAM JOHN |
分类号 |
A61K39/395;C07H21/04;C07K14/475;C07K14/52;C07K16/00;C07K16/30;C07K16/44;C07K16/46;C12N;C12N15/00;C12P21/04;C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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