| 摘要 |
Methods, kits, arrays, and biosensors for detecting proteins, modified-proteins, protein-protein interactions, protein-DNA interactions, autoantibodies, and protein-small molecule interactions, are disclosed. A representative method of detecting proteins of the present invention includes exposing a solid support to a solution containing proteins; conjugating proteins to the solid support; exposing the solide support to a plurality of types of DNA-conjugated antibodies, wherein each type of DNA-conjugated antibody has an affinity for a specified protein; forming a complex between a protein conjugated with the solid support and a type of DNA-conjugated antibody when the protein is the specified protein for which the DNA-conjugated antibody has an affinity; separating the complex from the solution of proteins and the DNA-conjugated antibodies; releasing DNA from the DNA-conjugated antibodies; and detecting the DNA, wherein each DNA indicates the presence of the specified proteins.
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