发明名称 |
Osteogenic growth oligopeptides as stimulants of hematopoiesis |
摘要 |
The present invention relates to a pharmaceutical composition comprising as an effective ingredient an oligopeptide identical or analogous to the C-terminal portion of OGP, having stimulatory activity on the production of hematopoietic cells. Preferred oligopeptides that are used are Tyr-Gly-Phe-Gly-Gly, Tyr-Gly-Phe-His-Gly, Gly-Phe-Gly-Gly or Met-Tyr-Gly-Phe-Gly-Gly. More specifically, these oligopeptides enhance the engraftment of bone marrow transplants, hemopoietic reconstruction, bone marrow re-population and peripheral stem cell mobilization, preferably after chemotherapy or irradiation. The invention further provides methods of treatment and for using these oligopeptides in the preparation of pharmaceutical compositions.
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申请公布号 |
US2005004037(A1) |
申请公布日期 |
2005.01.06 |
申请号 |
US20040766527 |
申请日期 |
2004.01.29 |
申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM |
发明人 |
BAB ITAI;CHOREV MICHAEL;SHTEYER ARYE;MUHLRAD ANDRAS;MANSUR NURA;GUREVITCH OLGA;GREENBERG ZVI;ROSINI SERGIO;TRASCIATTI SILVIA;PETRINI MARIO |
分类号 |
A61K35/12;A61K35/14;A61K35/28;A61K38/00;A61K38/07;A61K38/08;A61K38/22;A61P7/00;A61P7/06;A61P35/00;A61P35/02;A61P37/00;A61P41/00;A61P43/00;C12N5/0789;(IPC1-7):A61K38/08;A61K38/06 |
主分类号 |
A61K35/12 |
代理机构 |
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