发明名称 Osteogenic growth oligopeptides as stimulants of hematopoiesis
摘要 The present invention relates to a pharmaceutical composition comprising as an effective ingredient an oligopeptide identical or analogous to the C-terminal portion of OGP, having stimulatory activity on the production of hematopoietic cells. Preferred oligopeptides that are used are Tyr-Gly-Phe-Gly-Gly, Tyr-Gly-Phe-His-Gly, Gly-Phe-Gly-Gly or Met-Tyr-Gly-Phe-Gly-Gly. More specifically, these oligopeptides enhance the engraftment of bone marrow transplants, hemopoietic reconstruction, bone marrow re-population and peripheral stem cell mobilization, preferably after chemotherapy or irradiation. The invention further provides methods of treatment and for using these oligopeptides in the preparation of pharmaceutical compositions.
申请公布号 US2005004037(A1) 申请公布日期 2005.01.06
申请号 US20040766527 申请日期 2004.01.29
申请人 YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM 发明人 BAB ITAI;CHOREV MICHAEL;SHTEYER ARYE;MUHLRAD ANDRAS;MANSUR NURA;GUREVITCH OLGA;GREENBERG ZVI;ROSINI SERGIO;TRASCIATTI SILVIA;PETRINI MARIO
分类号 A61K35/12;A61K35/14;A61K35/28;A61K38/00;A61K38/07;A61K38/08;A61K38/22;A61P7/00;A61P7/06;A61P35/00;A61P35/02;A61P37/00;A61P41/00;A61P43/00;C12N5/0789;(IPC1-7):A61K38/08;A61K38/06 主分类号 A61K35/12
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