PROTEIN CRYSTAL COMPRISING THE PROCESSIVITY CLAMP FACTOR OF DNA POLYMERASE AND A LIGAND, AND ITS USES

摘要

The present invention relates to a protein crystal comprising the processivity clamp factor of DNA polymerase and a peptide of about 3 to about 30 amino acids, in particular of about 16 amino acids, said peptide comprising all or part of the processivity clamp factor binding sequence of a processivity clamp factor interacting protein, such as prokaryotic Pol I, Pol II, Pol III, Pol IV, Pol V, MutS, ligase I, alpha subunit of DNA polymerase, UmuD or UmuD', or eukaryotic pol ϵ, pol delta, pol eta, pol iota, pol kappa.