METHOD OF PREPARING CIS-8B-METHYLDECAHYDRO-2A,4A,6A,8A-TETRAAZACYCLOPENTA[FG]ACENAPHTHYLENE, CIS-DECAHYDRO-2A,4A,6A,8A-TETRAAZACYCLOPENTA[FG]ACENAPHTHYLENE, CYCLENE AND FUNCTIONALISED CYCLENES

摘要

The invention relates to a method of preparing cyclene having formula (I) from triethylenetetraamine having formula (VIII) or ethylenediamine having formula (VIII'). The inventive method is characterised in that it comprises one of the following series of successive steps. The first series of steps (I) comprises a step A involving the one-pot preparation of the compound having formula (IIa) from the compound having formula (VIII) as defined above, followed by a step B involving the transformation of the compound having formula (IIa) into cyclene having formula (I). The second series of steps (II) comprises a step C involving the preparation of the compound having formula (IIb) from the compound having formula (VIII) as defined above, followed by a step D involving the transformation of the compound having formula (IIb) into cylcene having formula (I). Finally, the third series of steps (III) comprises a step E involving the one-pot preparation of the compound having formula (IIa), as defined above, from the compound having formula (VIII) as defined above, followed by a step B involving the transformation of the compound having formula (IIa) into cyclene having formula (I).