发明名称 |
PROCESS FOR MANUFACTURING PURIFIED PHOSPHORODIAMIDITE |
摘要 |
<p>A scalable process for purification of phosphorodiamidite includes steps of solubilizing a crude phosphorodiamidite in an apolar organic solvent, contacting the non-polar organic solvent with a polar phase comprising a polar organic solvent to remove impurities from the solubilized phosphorodiamidite, and removing the non-polar organic solvent from the phosphorodiamidite.</p> |
申请公布号 |
EP1492800(A2) |
申请公布日期 |
2005.01.05 |
申请号 |
EP20030738877 |
申请日期 |
2003.04.11 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
SONG, QUANLAI;ROSS, BRUCE |
分类号 |
C07F9/02;C07F9/24;C07F9/655;C07H19/10;C07H19/20;(IPC1-7):C07F9/28 |
主分类号 |
C07F9/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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