| 摘要 |
An in vitro method of determining activation or inactivation of the atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) hormonal systems, the method comprising detecting the presence or amount of atrial and brain natriuretic peptide prohormones (proANP and proBNP) or fragments thereof in a sample. The method can be used in the diagnosis or treatment of heart failure in an individual. Also disclosed is an agent that comprises proANP, ANP or NT-proANP and proBNP, BNP, or NT-proBNP. A method of identifying a substance that binds specifically to proANP, ANP or NT-proANP and proBNP, BNP, or NT-proBNP is also disclosed. |
