Prodrugs and conjugates of selenium-containing compounds and methods of use thereof

摘要

A prodrug of the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="61" wi="40" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry> where R' is a sugar that is of the formula (CHOH)<Sub>n</Sub>CH<Sub>2</Sub>OH, where n is 1 to 5, or
R' is hydrogen, an alkyl or aryl group, or
R' is =O, and
R" groups are the same or different and may be hydrogen, alkyl, alkoxy, or carboxy.
or a prodrug of the formula;
<Chemistry id="chema02" num="0002"><Image id="ia02" he="30" wi="53" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry> where R' is a sugar and is of the formula (CHOH)<Sub>n</Sub>CH<Sub>2</Sub>OH, where n is 1 to 5, or
<!-- EPO <DP n="8001"> -->R' is an alkyl or aryl group, or
R' is =O, and
R" is an alkoxy or an amine group.
or a prodrug of the formula;
<Chemistry id="chema03" num="0003"><Image id="ia03" he="24" wi="40" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry> R is COOH or H, and
R' is a sugar of the formula (CHOH)<Sub>n</Sub>CH<Sub>2</Sub>OH, where n is 1 to 5, or
R' is an alkyl or aryl group, or
R' is =O.