| 摘要 |
1457237 Cephem compounds RECHERCHE ET INDUSTRIE THERAPEUTIQUES 21 May 1975 [22 May 1974 2 Jan 1975] 21816/75 Heading C2C The invention comprises compounds of formula and their non-toxic pharmaceutically acceptable salts. In examples, these compounds are prepared by converting benzyl or tert-butyl thienylacetate to the corresponding malonate monoester, converting this to monobenzyl (or tert - butyl)mono(2,5 - dioxopyrrolidin - 1 - yl)- thienylmalonate, reacting the latter with the corresponding amino / methyltetrazolylthiomethyl cephen compound, and finally hydrolysing the thus-formed side-chain monoester of I. Thereapeutic compositions having antibacterial activity comprise compounds of the above formula and may be administered by injection. |
