Process for applying an antibiotic coating on bodies with interconnected microcavities (variants), body with interconnected microcavities with antibiotic coating (variants) and use thereof

摘要

The invention refers to medicine and veterinary medicine, in particular to a process for applying an antibiotic coating on bodies with interconnected microcavities, to a body with coating applied by such process and to the use thereof.The process for applying an antibiotic coating on bodies with interconnected cavities includes introduction into the microcavities by impregnation, atomization or dripping of a solution of gentamicine pentakisdodecyl sulphate; gentamicine tetrakisdodecyl sulphate; gentamicine pentakisdodecyl sulphonate or gentamicine tetrakisdodecyl sulphonate. As solvent is used methanol and/or ethanol, and/or N,N-dimethyl formamide, and/or dimethyl sulfoxide, afterwards the organic solvent is removed and onto the surface of the microcavities is formed a layer of gentamicine pentakisdodecyl sulphate, gentamicine tetrakisdodecyl sulphate, gentamicine pentakisdodecyl sulphonate, gentamicine tetrakisdodecyl sulphonate.The bodies with antibiotic coating, made of collagen or gelatine, or polyesters, or tricalcium phosphate, or hydroxylapatite, or titanium, or titanium alloys, or high-quality steel, are used in the capacity of implant.