发明名称 |
Position-independent and tissue specific expression of a transgene in milk of transgenic animals |
摘要 |
The present invention relates to an isolated insulator DNA molecule consisting of the 5' and 3' regions of the porcine wrap gene locus and a method for insulating the expression of an introduced heterologous gene from silencing and variegation effect in chromatin into which the gene has integrated. The invention is also directed to mammalian cells comprising said insulator DNA molecule and non human animals obtained therefrom, which are preferably able to express a polypeptide of interest in milk.
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申请公布号 |
US2004265806(A1) |
申请公布日期 |
2004.12.30 |
申请号 |
US20030451503 |
申请日期 |
2003.06.23 |
申请人 |
RIVAL SYLVIE;VIGLIETTA CELINE;ATTAL JOE;HOUDEBINE LOUIS-MARIE |
发明人 |
RIVAL SYLVIE;VIGLIETTA CELINE;ATTAL JOE;HOUDEBINE LOUIS-MARIE |
分类号 |
A01K67/027;C07K14/47;C12N5/10;C12N15/09;C12N15/63;C12N15/85;(IPC1-7):C12Q1/68;C07H21/04;C12N9/20 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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