发明名称 |
Inhibitors against complex II of electron transport system |
摘要 |
An electron transport system complex II inhibitor comprising 2-pyridinol derivative represented by the general formula [I] wherein R is alkyl or alkenyl optionally having substituent containing halogen, or its tautomer 2-pyridone derivative represented by the general formula [II] wherein R is alkyl or alkenyl optionally having substituent containing halogen, or salt thereof as an active ingredient. The compound inhibits the complex II strongly with nM order activity. Consequently, 2-pyridinol derivative or its tautomer, 2-pyridone derivative, are useful as the complex II inhibitor.
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申请公布号 |
US2004266835(A1) |
申请公布日期 |
2004.12.30 |
申请号 |
US20040489964 |
申请日期 |
2004.08.17 |
申请人 |
OMURA SATOSHI;SHIOMI KAZURO;TOMODA HIROSHI;MASUMA ROKURO;KITA KIYOSHI |
发明人 |
OMURA SATOSHI;SHIOMI KAZURO;TOMODA HIROSHI;MASUMA ROKURO;KITA KIYOSHI |
分类号 |
A61K31/44;A61P43/00;C07D213/69;C12N1/14;C12P1/02;C12P17/12;(IPC1-7):C07D211/84;A61K31/441 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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