TARTRATE SALTS OF 5,8,14-TRIAZATETRACYCLO [10.3.1.02,11.04,9]-HEXADECA-2(11),3,5,7,9- PENTAENE AND PHARMACEUTICAL COMPOSITIONS THEREOF

摘要

The present invention is directed to the tartrate salts of 5,8,14-triazatetracyclo [10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene of formula and pharmaceutical compositions thereof. The present invention in particular is directed to the L-tartrate salt, and further to the various polymorphs of the L-tartrate salt, including two distinct anhydrous polymorphs (referred herein as Forms A and B)and a hydrate polymorph (referred to herein as Form C). In addition, the present invention is also directed to the D-tartrate salt of 5,8,14-triazatetracyclo [10.3.1.02,11.04,9]-pentaene and the various polymorphs thereof, as well as the D,L-tartrate salt thereof and its polymorphs, and the meso-tartrate salt thereof and its polymorphs.