| 摘要 |
Compounds possessing 5HT7 activity of formula (I) or a pharmaceutically acceptable salt thereof are disclosed: in which X is a 5 or 6 membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulfur; R2 is halogen, C1-6alkyl, haloC1-6alkyl, hydroxy, C1-6alkoxy or C1-6alkylthio; R3 is hydrogen, C1-6alkyl, hydroxy or oxo; m is 0, 1 or 2; p is 0, 1 or 2; n is 1 or 2; R4 and R5 are both hydrogen, or R4 and R5 combine together to form a further group: -(CH2)q- where q is 2 or 3; D is a single bond, C1-4alkylene, C=O or oxygen; Z is either a group (a): in which R1 is halogen, C1-6alkyl, cyano, haloC1-6alkyl, C3-7cycloalkyl, C1-6alkoxy, hydroxy, amino, mono- or di-C1-6alkylamino, acylamino, nitro, carboxy, C1-6alkoxycarbonyl, C1-6alkylthio, C1-6alkylsulfinyl, C1-6alkylsulfonyl, sulfamoyl, mono- and di-C1-6alkylsulfamoyl, carbamoyl, mono- or di-C1-6alkylcarbamoyl, C1-6alkylsulfonamido, arylsulfonamido, aryl, arylC1-6alkyl, arylC1-6alkoxy, aryloxy or arylthio, and y is 0, 1, 2 or 3; or a group (b): in which P is a 5 membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulfur; R8 is hydrogen, C1-6alkyl, hydroxy or oxo; R6 and R7 form the residue of a phenyl ring or a 6 membered heteroaryl ring comprising from one to three heteroatoms selected from nitrogen, oxygen and sulfur and optionally substituted with one or two substitutents which may be the same or different and selected from the group consisting of halogen, C1-6alkyl, cyano, haloC1-6alkyl, C3-7cycloalkyl, C1-6alkoxy, hydroxy, amino, mono- or di-C1-6</subscri
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