SUBSTITUTED ISOXAZOLE ALKYLAMINE DERIVATIVE AND AGRI- AND HORTICULTURAL FUNGICIDE

摘要

Isoxazole alkylamine derivatives (I) are new. Isoxazole alkylamine derivatives of formula (I) are new. [Image] R 1, R 2H, lower alkenyl, lower alkynyl, OAlk, COOAlk, SAlk, halo OH, COOH, CN or optionally substituted Alk or Cyc; Alk : lower alkyl; Cyc : cycloalkyl; X : (CR 3R 4) m(CR 5R 6) n, (CR 3R 4) mA(CR 5R 6) nor (CR 3R 4) m(CO) p(D) qN=CR 7; R 3-R 6R 1, NH 2, NHA or N(Alk) 2, or CR 1R 2, CR 3R 4, CR 5R 6optionally substituted Cyc; A : O, S, SO, SO 2, NR 12, CO, NHCO, CONH, CC, NHCONH, OCONH, CH=N or CR 14=CR 15; R 12, R 14, R 15, R 7H or Alk; m, n : 0-3; p, q : 0 or 1; D : O or NH; Y 1ON=CR 8R 9, Y 2or optionally substituted Alk; R 8, R 9H or optionally substituted Alk or phenyl, or CR 8R 9cycloalkyl; Y 2alkenyl, alkynyl, Cyc, lower cycloalkenyl, phenyl, naphthyl, heteroaryl or aliphatic heterocyclyl (all optionally substituted); Z : (CR 10R 11) ror B'(CR 10R 11) r; R 10, R 11R 1, or CR 10R 11optionally substituted Cyc; r : 0-3; B' : O, S or NR 13, and R 13H or Alk; provided that: (i) X = a bond, m, n = 0 then Y 1is not 4-hydroxy-3,5-di-tert-butoxyphenyl; (ii) Z = a bond and r = 0 or Z = NH, r = 0 and B' = NH, R 1, R 2= H, then Y 1, Y 2are not unsubstituted phenyl, and (iii) R 1, R 2= H, Z = bond, r = 0, then Y 2is not 4-hydroxycinnolin-3-yl. ACTIVITY : Fungicide. In tests, phenyl [(3-isopropyl-5-isoxazolyl)methyl]carbamate at 200 ppm gave 100% control against Pyricularia oryzae. MECHANISM OF ACTION : None given.