IMMUNOGENIC MUTANT HUMAN IMMUNODEFICIENCY VIRUS GP120 POLYPEPTIDES, AND METHODS OF USING SAME

摘要

Immunogenic mutant HIV gp120 polypeptides that contain at least one mutation in at least one epitope that specifically binds non-neutralizing antibodies are provided. Also provided are methods of making such HIV neutralizing antibodies using such immunogenic mutant gp120 polypeptides. In addition, methods of inducing an HIV neutralizing antibody response in a subject are provided.