Use of pyridoxal phosphate derivatives for the treatment of diabetes and related complications

摘要

Treating diabetes mellitus, hyperinsulinemia , diabetes-induced hypertension, or diabetes-related damage to e.g. blood vessels and eyes in mammal comprises administering pyridoxal-5'-phosphate, pyridoxamine, pyridoxal, pyridoxine, 3-acylated pyridoxal analog and/or acid addition salts of these, optionally in combination with insulin and/or hypoglycemic compound. Treating diabetes mellitus, hyperinsulinemia, diabetes-induced hypertension or diabetes-related damage to blood vessels, eyes, kidneys, nerves, autonomic nervous system, skin, connective tissue or immune system in a mammal comprises: (a) administering a compound (I) selected from pyridoxal-5'-phosphate, pyridoxamine, pyridoxal, pyridoxine, a 3-acylated pyridoxal analog and/or their acid addition salts; or (b) concurrently administering (I) in combination with insulin or a hypoglycemic compound. ACTIVITY : Antidiabetic.