发明名称 |
CIRCULAR DNA MOLECULE HAVING A CONDITIONAL ORIGIN OF REPLICATION, PROCESS FOR THEIR PREPARATION AND THEIR USE IN GENE THERAPY |
摘要 |
A circular DNA molecule, useful for gene therapy, comprising at least one nucleic acid sequence of interest, characterised in that the region allowing the replication thereof has an origin of replication with a functionality in a host cell that requires the presence of at least one specific protein foreign to said host cell. A method for preparing same, cells incorporating said DNA molecules and uses thereof in gene therapy are also described. |
申请公布号 |
WO2004033664(A3) |
申请公布日期 |
2004.12.29 |
申请号 |
WO2003US32512 |
申请日期 |
2003.10.14 |
申请人 |
GENCELL SA;AVENTIS PHARMA INC |
发明人 |
SOUBRIER FABIENNE |
分类号 |
C12N1/21;A61K48/00;C07K14/50;C07K14/82;C12N15/00;C12N15/64;C12N15/69;C12N15/70;C12N15/74;C12R1/01 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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