| 摘要 |
The invention relates to 5,10-methylene-(6R)-,-(6S)-or (6R,S)-tetrahydrofola te (MTHF) pharmaceutical compounds whose stability is due to the adjustment thereof to a basic pH value and to a simultaneous citrate use. Said stabilisation is self-producible in the absence of a reducing agent. Said invention is particularly suitable for preparing lyophilization solution or lyophilisates or dry powders and dry mixtures since the stable MTHF solution s can be filled at the high concentration thereof into corresponding recipient s like, for example vials, ampoules etc. Said lyophilisates are surpassingly storable and stable. They are easily reconstituted by adding water or aqueou s solutions, thereby providing diluted injection solutions ready for use with an excellent stability. Said invention also makes it possible to produce highly concentrated calcium or acid MTHF salts, even difficult-to-dissolve, in the form of isotonic physiologically compatible solutions. |
