METHODS AND COMPOSITIONS FOR MODULATING STEM CELL GROWTH AND DIFFERENTIATION
摘要
The invention can be summarized as follows. There is provided methods and compositions for modulating proliferation and/or lineage commitment of stem cells by modulating the Wnt signalling pathways. Modulators of the Wnt signalling pathways and screening methods to identify modulators are also provided. The methods of the invention may be conducted in vitro or in vivo to induce or inhibit stem cell proliferation and/or lineage commitment, and are particularly useful for in vivo stimulation of proliferation and/or lineage commitment of resident stem cells in a tissue.
申请公布号
WO2004113513(A2)
申请公布日期
2004.12.29
申请号
WO2004CA00941
申请日期
2004.06.25
申请人
OTTAWA HEALTH RESEARCH INSTITUTE;RUDNICKI, MICHAEL;SEALE, PATRICK;POLESSKAYA, ANNA;FORTIN, ANOUK