发明名称 |
PROTEIN C DERIVATIVES |
摘要 |
<p>Novel human protein C derivatives are described. These derivatives have increased anti-coagulation activity and resistance to inactivation by serpins, compared to wild-type protein C and retain the biological activity of the wild-type human protein D. These derivatives will require either less frequent administration and/or smaller dosage than wild-type human protein C in the treatment of acute coronary syndromes, vascular occlusive disorders, hyper coagulable states, thrombotic disorders and disease states predisposing to thrombosis.</p> |
申请公布号 |
EP1255821(B1) |
申请公布日期 |
2004.12.29 |
申请号 |
EP20010904786 |
申请日期 |
2001.01.19 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
GERLITZ, BRUCE, EDWARD;JONES, BRYAN, EDWARD |
分类号 |
C12N15/09;A61K38/00;A61K38/43;A61K38/48;A61K45/00;A61K48/00;A61P7/02;A61P9/00;A61P9/08;A61P9/10;A61P31/04;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/50;C12N9/64;C12N15/57;C12R1/91;(IPC1-7):C12N9/64 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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