发明名称 Living radical polymerization initiator comprising a functional group capable of reacting with polypeptides or the like, comb polymer obtained therewith, polypeptide conjugates and drugs obtained therefrom
摘要 <p>The application provides a method of producing a comb polymer comprising the steps of (a) Providing: (i) a plurality of monomers which are linear, branched or star-shaped, substituted or non-substituted, and have an olefinically unsaturated moiety, the olefinically unsaturated moiety being capable of undergoing addition polymerisation; (ii) an initiator compound; the initiator compound comprising a homolytically cleavable bond, (iii) a catalyst capable of catalysing the polymerisation of the monomer, and (b) Causing the catalyst to catalyse, in combination with the initiator, the polymerisation of a plurality of the monomers to produce the comb polymer catalyst and polymers obtainable by the process are also provided. Preferably, the comb polymer is capable of binding proteins and may be produced from monomers which are alkoxy polyethers, such as poly(alkyleneglycol) or polytetrahydrofuran.</p>
申请公布号 AU2004249489(A1) 申请公布日期 2004.12.29
申请号 AU20040249489 申请日期 2004.06.18
申请人 WARWICK EFFECT POLYMERS LIMITED 发明人 LEI TAO;DAVID HADDLETON;FRANCOIS LECOLLEY;GIUSEPPE MANTOVANI;ADRIAN CARMICHAEL
分类号 C08F2/38;A61K47/48;C07D207/40;C07D207/404;C07D207/44;C07D207/452;C07D209/48;C07D213/70;C07D233/54;C07D249/18;C07D251/26;C07D251/42;C07D491/18;C08F4/00;C08F290/06;C08F293/00;C08F299/02 主分类号 C08F2/38
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