发明名称 |
SUSTAINED-RELEASE FINE GRANULAR PREPARATION OF HUMAN GROWTH HORMONE AND PROCESS FOR PRODUCING THE SAME |
摘要 |
It is intended to provide a sustained release fine granular preparation of human growth hormone having both of biodegradability and sustained-release performance with the use of an organic solvent in a minimized amount, ensuri ng the release of human growth hormone over 3 days or longer, showing regulated initial burst release, being able to have human growth hormone at a content of 10% or more, allowing the quantitative adsorption/encapsulation of sustained - release fine granules of human growth hormone up to 20%, and having favorabl e dispersion and needle penetration properties, and a process for producing th e same. This preparation comprises a porous apatite derivative, human growth hormone and a water-soluble divalent metal compound.
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申请公布号 |
CA2524256(A1) |
申请公布日期 |
2004.12.29 |
申请号 |
CA20042524256 |
申请日期 |
2004.06.15 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY AGENCY;GALENISEARCH, LABORATORIES;INDEPENDENT ADMINISTRATIVE INSTITUTION, NATIONAL INSTITUTE FOR MATERIALS SC |
发明人 |
TANAKA, JUNZOU;IKOMA, TOSHIYUKI;NIIMI, JUN;MIYAMOTO, YOKO;OGAWA, YASUAKI;FUJII, TAKAO |
分类号 |
A61K9/52;A61K38/27;A61K9/14;A61K9/16;A61K47/02;A61K47/04;A61P5/10 |
主分类号 |
A61K9/52 |
代理机构 |
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