N-SUBSTITUTED 6,8-DIALKOXY-1,2,3,4-TETRAHYDRO-1H-ISOQUINOLINE AS POTASSIUM CHANNELS MODULATORS

摘要

The invention relates to compounds having the Formula (I) or a salt, or a physiologically functional derivative, or a prodrug thereof, (I) wherein Z is carbonyl or sulfonyl; R<1 >is alkyl, alkenyl, alkynyl, aryl, H, halogen, haloalkyl, haloalkoxy, hydroxyalkyl, cycloalkyl or heteroaryl; R<2> is H, OH, -CH2-SO2-alkyl, -CH2-SO2-cycloalkyl, -CH2-SO2-aryl, -CH2-SO2-heteroaryl, alkylamine, alkenylamine, alkynylamine, cycloalkylamine, arylamine, heteroarylamine, aryl, haloalkyl, haloalkoxy, hydroxyalkyl, cycloalkyl, heteroaryl or a linear or branched alkyl, alkenyl, alkynyl, which can optionally be substituted by one or more substituentes R<3>; R<3> is H, alkyl, alkenyl, alkynyl, cycloalkyl, -CO2R<4>, -CONHR<4>, -CONR<4>R<4>, - CR<4>O, SO2R<4>, -NR<4>-CO-R<4>, alkoxy, alkylthio, -OH, -SH, -O-aryl, -O-cycloalkyl, -S-aryl, -S-cycloalkyl, hydroxyalkyl, halogen, haloalkyl, haloalkoxy, CN, NO2, hydroxyalkylamine, aminoalkyl, alkylamine, aryl or heteroaryl; R<4> is H, halogen, alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, alkylthio, -O-aryl, - O-cycloalkyl, OH, SH, -S-aryl, -S-cycloalkyl, hydroxyalkyl, haloalkyl, haloalkoxy, hydroxyalkyl-amine, aminoalkyl, alkylamine, aryl or heteroaryl; R<5> is alkyl, alkenyl or alkynyl.