CANNABINOID DERIVATIVES, METHODS OF MAKING, AND USE THEREOF

摘要

1'-substituted cannabinoid derivatives of delta-8-tetrahydrocannabinol, delt a- 9-tetrahydrocannabinol, and delta-6a-10a-tetrahydrocannabinol that have affinity for the cannabinoid receptor type-1 (CB-1) and/or cannabinoid receptor type~2 (CB-2). Compounds having activity as either agonists or antagonists of the CB-1 and/or CB-2 receptors can be used for treating CB-1 or CB-2 mediated conditions.