| 摘要 |
This invention provides compounds of the formula I:wherein:R1 and R2 are independently H, OH, OAc, alkylaryl, alkylheteroaryl, 1-propynyl, 3-propynyl, and substituted alkyl, O(alkyl), aryl, or heteroaryl;or R1 and R2 are joined to form a ring comprising -CH2(CH2)nCH2- where n=0-5; -CH2CH2C(CH3)2CH2CH2-; -O(CH2)mCH2- where m=1-4; O(CH2)pO- where p=1-4; -CH2CH2OCH2CH2-; -CH2CH2N(H or alkyl)CH2CH2-;or R1 and R2 together comprise a double bond to C(CH3)2, C(cycloalkyl), O, or C(cycloether);R3 is H, OH, NH2, COR<A>, or optionally substituted alkenyl or alkynyl groups;R<A>=H or optionally substituted alkyl, alkoxy, or aminoalkyl groups;R4=H, halo, CN, NH2, or optionally substituted alkyl, alkoxy, or aminoalkyl;R5 is optionally substituted benzene ring; five or six membered heterocyclic ring; 4 or 7-substituted indole or a substituted benzothiophene;or pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions and methods of using the compounds as progesterone receptor antagonists.
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