| 摘要 |
Piperazine or piperidine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided. The piperazine or piperadine compounds are characterized by the formula:Formula Iwherein:A is oxygen; n is an integer of 1 to 6; X and Y can be the same or different and are hydrogen, halogen, nitro, alkyl or halalkyl, Z is carbon or nitrogen; and phi is phenyl, naphthyl, thienyl or pyridinyl.When Z is carbon, R is hydrogen, cyano, hydroxy, -COOCH3, -CH20H or -COOH; R1 is 4-fluorophenyl, 4-chlorophenyl, 4-trifluoromethyl, 3-trifluoromethyl-4 -chlorophenyl 4-bromophenyl), 4-(2-keto-1-benzimidazolinyl or 1-phenyl 1, 3, 8-triazaspiro [4,5] decan-4-one. When Z is nitrogen, R and R1 combined arewherein R3 is halo, alkyl, cyano or nitro and R2 can be hydrogen orwherein R4 is halo, alkyl, cyano, nitro, alkylnyl or alkenyl
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