EXTENDED RELEASE COMPOSITION CONTAINING TRAMADOL

摘要

The present invention relates to a once daily extended release pharmaceutical preparation of Tramadol or its acceptable pharmaceutical salts. The preparation provides, effective blood concentration for a period of about 24 hours with reduced peak concentrations. It is characterized that effective Tramadol levels appear within the first hours after administration, the time to maximal Tramadol content T>max< is at least 10 hours and the peak Tramadol concentration is less than three times the concentration obtained after 24 hours of said administration.