1-PHENYL-2-OXO-3-SULFONYLAMINO-PYRROLIDINE DERIVATIVES AND RELATED COMPOUNDS AS FACTOR XA INHIBITORS FOR THE TREATMENT OF ACUTE VASCULAR DISEASES

摘要

The invention relates to compounds of formula (I) wherein: R<1> represents a group selected from: formula (II) each ring of which optionally contains a further heteroatom N, Z represents an optional substituent halogen, alk represents alkylene or alkenylene, T represents S, O or NH; R<2> represents -C1-6alkyl, -C1-3alkylCN, -C0-3alkylR<c>, -C1-3alkylR<f>, -C2-3alkylNR<a>R<b>, -C2-3alkylOC1-6alkyl, -C2-3alkylOC1-3alkylCONR<a>R<b>, with the proviso that R<2> does not represent C2-3alkylmorpholino; X represents phenyl or a 5- or 6- membered aromatic heterocyclic group containing at least one heteroatom selected from O, N or S, each of which is optionally substituted by 0-2 groups selected from: halogen, -C1-4alkyl, -C2-4alkenyl, -CN, -CF3, -NR<a>R<b>, -C0-4alkylOR<e>, -C(O)R<d> and -C(O)NR<a>R<b>; Y represents a substituent selected from hydrogen, halogen, -C1-4alkyl, -C2-4alkenyl, -NR<a>R<b>, -NO2, -C(O)NR<a>R<b>, -N(C1-4alkyl)(CHO), -NHCOC1-4alkyl, -NHSO2R<d>, -C0-4alkylOR<e>, -C(O)R<d>, -S(O)nR<d>, or -S(O)2NR<a>R<b>; The other substituents are as defined in claim 1.