| 摘要 |
The invention describes continuously growing, normal T-lymphocyte cell lines (T-lymphocyte lines) comprising nucleic acids sequences encoding immune receptors, for example T-cell receptors, with defined antigen specificity, wherein the nucleotide sequences are operably linked to an expression signal not natively associated therewith. Further, this invention is directed to methods of adoptive immunotherapy. In particular methods for allogeneic adoptive immunotherapy are provided. This invention further relates to methods for adoptive immunotherapy in the treatment of cancer in a human being, including therapy of malignant melanoma. Moreover this invention relates to methods for cultivating unlimited amounts of activated T-lymphocytes stably expressing a T-cell receptor with defined tumour antigen specificity and reactivity.
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