Epitopic fragments of Nogo, including Nogo 45-66, elicit a specific and strong T cell response, and a B cell response. T cells reactive to Nogo antigens are capable of ameliorating ongoing disease, which may be induced with other antigens. The present invention provides compositions and methods for the identification and use of Nogo epitopic fragments in the treatment of immune related disease.
申请公布号
WO2004110353(A2)
申请公布日期
2004.12.23
申请号
WO2004US15387
申请日期
2004.05.14
申请人
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;STEINMAN, LAWRENCE;GARREN, HIDEKI;FONTOURA, PAULO