发明名称 |
Process for producing purine nucleotides |
摘要 |
Purine nucleotides are produced by culturing a microorganism having the ability to produce a precursor of the purine nucleotide and carrying an introduced DNA which can express an enzyme capable of synthesizing the purine nucleotide from the precursor upon induction; allowing the purine nucleotide precursor to accumulate in the culture; inducing the expression of the enzyme; allowing the purine nucleotide formed to accumulate in the culture; and recovering the purine nucleotide. Suitable microorganisms include Corynebacterium ammoniagenes which are induced to express GMP synthetase/XMP aminase and inosine-guanosine kinase for use in producing IMP and GMP, especially from the nucleotide precursor XMP.
|
申请公布号 |
US2004259212(A1) |
申请公布日期 |
2004.12.23 |
申请号 |
US20030632906 |
申请日期 |
2003.08.04 |
申请人 |
KYOWA HAKKO KOGYO CO., LTD |
发明人 |
TAKANO YUTAKA;IKEDA MASATO;FUJIO TATSURO |
分类号 |
C12N9/00;C12N9/12;C12N9/16;C12P19/32;(IPC1-7):C12P19/30;C12N1/20 |
主分类号 |
C12N9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|