STRAIN BELONGING TO THE GENUS STREPTOMYCES AND BEING CAPABLE OF PRODUCING NEMADICTIN AND PROCESS FOR PRODUCING NEMADICTIN USING THE STRAIN

摘要

To obtain nemadictin as C-13 hydroxylnemadictin to which a saccharide can add, a strain capable of producing C-13 hydroxylnemadictin is constructed by modifying nemadictin aglycon biosynthesis genes. Further, a C-13 glycosylnemadictin-producing strain is constructed by transferring aveBI-BVIII genes participating in the glycosylation of Avermectin and the biosynthesis of oleandrose. Thus, C-13 hydroxylnemadectin and nemadictin glycosylated at the C-13 position can be efficiently obtained with the use of the producing strains constructed molecular genetic techniques and it is expected that the biological activities thereof can be thus improved.