Novel endothelially expressed dnas and proteins, and their use

摘要

The present invention relates to novel, specifically expressed proteins and to nucleic acid sequences or transgenic nucleic acid constructs which encode the proteins. The invention also relates to transgenic organisms or animals which harbor the nucleic acid sequences or recombinant nucleic acid constructs and also to monoclonal or polyclonal antibodies and binding factors which are directed against the isolated proteins. The invention furthermore relates to a process for finding substances which possess specific binding affinity with the proteins according to the invention, and to a process for qualitatively or quantitatively detecting the nucleic acid sequences according to the invention or the proteins according to the invention. The invention furthermore relates to the use of nucleic acid sequences and proteins. The invention also encompasses processes for finding substances which modulate the function of the proteins according to the invention. It also relates to the use of these proteins for producing drugs.